University of Central Florida (UCF) ZOO3744 Neurobiology Practice Exam 2

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Which of the following peptides is known to inhibit gastrointestinal motility?

Substance P

Vasoactive Intestinal Polypeptide

CCK

Somatostatin

Somatostatin is a peptide that plays a crucial role in the regulation of various physiological processes, including the inhibition of gastrointestinal motility. It primarily acts by inhibiting the release of a number of other hormones and substances that promote digestion and intestinal movement. In the gastrointestinal tract, somatostatin reduces the secretion of gastrin and other peptides, consequently slowing down the propulsion and contractions of the intestines.

This inhibition of gastrointestinal motility can lead to decreased digestive activity, which can be beneficial in certain physiological conditions, such as during stress when energy conservation is priority. Understanding the action of somatostatin is essential in neurobiology and gastrointestinal physiology, as it highlights the complex interplay between digestive hormones and their effects on gut function.

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